Convenient synthesis of 1,2,5-(1,3,4)-oxadiazolyl-1,2,4-oxadiazoles.
V. N. Yarovenko,* I. V. Zavarzin, and M. M. Krayushkin
N.D. Zelinsky Institute of Organic Chemistry. Russian Academy of Sciences,
47 Leninsky prosp. 117913 Moscow, Russian Federation. E-mail: nord69@glasnet.ru
Received: 27 August 1997 / Uploaded: 28 August 1997
Abstract: Convenient synthesis of 1.2.5-(1.3.4)-oxadiazolyl-1,2,4-oxadiazoles by reaction between corresponding amidoximes and nitriles in present of ZnCl2 and HCL has been elaborated.
In previous papers we described efficient synthesis of 1,2,4-oxadiazoles by reaction amidoximes with nitriles (1) and investigated the mechanism of the reaction (2).
At present paper using our approaches we synthesize unknown 1,2,4-oxadiazoles contaning 1,2,5-(1,3,4)-oxadiazoles.We faild to obtain this compounds by the literature methods.
The approach allows to synthesize 1,2,4-oxadiazole having both 1,2,5-and 1,3,4-oxadiazoles.
1.Yarovenko V.N.,Taralashvili V.K.,Zavarzin I.V.,Krayushkin M.M.,Tetrahedron,1990,Vol.46,N11,p.3941
2. Yarovenko V.N., Ugrak B.I., Krayushkin M.M.,Shirinyan V.Z., Zavarzin I.V., Russian Chemical Bulletin,1994,Vol.43,N4,p.627...
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